Persistent Increase in Serum Alkaline Phosphatase in a Patient with Monoclonal Gammopathy of Undefined Significance

Persistent Increase in Serum Alkaline Phosphatase in a Patient with Monoclonal Gammopathy of Undefined Significance

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We report the finding of alkaline phosphatase-immunoglobulin complex (macro-alkaline phosphatase (macro-ALP)) in a patient with persistently increased ALP activity.The identification of macro-ALP is important to rule out pathological old taylor whiskey 1933 price causes of increased ALP activity and to avoid unnecessary diagnostic investigation.The patient was subsequently diagnosed with vitamin D deficiency, gallstone pancreatitis, and monoclonal gammopathy of undefined significance (MGUS).Macro-ALP can coexist with disease that can increase serum ALP activity.

We report, for the first time, a case of macro-ALP in Jeans a patient with a monoclonal protein (M-protein).